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Calpain pharmacology and toxicology of calcium-dependent protease by

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Published by Taylor & Francis in Philadelphia, PA .
Written in English


  • Calpain -- Physiological effect.,
  • Calpain -- Pathophysiology.,
  • Calpain -- physiology.,
  • Calpain -- pharmacology.

Book details:

Edition Notes

Includes bibliographical references and index.

Statement[edited by] Kevin K.W. Wang, Po-Wai Yuen.
ContributionsWang, Kevin K. W., Yuen, Po-Wai.
LC ClassificationsQP609.C26 C35 1999
The Physical Object
Paginationxiv, 448 p. :
Number of Pages448
ID Numbers
Open LibraryOL384310M
ISBN 101560327138
LC Control Number98046860

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Overview The purpose of Calpain Methods and Prools is quite straightf- ward: it is to present the actual experimental methods used in many different laboratories for the study of calpain. It will provide the vital experimental detail, and the discussion of possible pitfalls, for Price: $   Calpain Hardcover – July 1, by Koichi Suzuki (Author) See all formats and editions Hide other formats and editionsAuthor: Koichi Suzuki. This volume brings together a plethora of protocols and experimental methods used by scientists to study calpains, their inhibitors, and their substrates. It also explores bioinformatic approaches to calpain substrate identification. The authors also examine specific substrates that have been proposed for the calpains. Highly practical and readily repeatable, Calpain Methods and Protocols offers investigators involved in basic and clinically oriented calpain research a gold-standard collection of powerful experimental tools for discovering the nature and function of calpains.

About this book Introduction The methods include in vitro techniques for the detection, expression, purification, and assay of µ- and m-calpain, supplemented with a wide range of system and tissue models for studying both the physiological functions and the effects of inhibitors on calpain. Calpain is a ubiquitously expressed cytosolic protease that has long been implicated in necrosis and has been found to be activated in some cases of apoptosis. Calpain is activated by elevated intracellular concentrations of calcium; therefore, it could be activated by . PR CALPAIN: SMART i: View protein in SMART SM calpain_III, 1 hit SM CysPc, 1 hit SM EFh, 2 hits: SUPFAM i: SSF SSF, 1 hit SSF SSF, 1 hit SSF SSF, 1 hit: PROSITE i: View protein in PROSITE PS CALPAIN_CAT, 1 hit PS EF_HAND_1, 2 hits PS EF_HAND_2, 3 hits. A calpain (/ ˈ k æ l p eɪ n /; EC , EC ) is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other ns constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain proteases, the small regulatory.

  The calpain family of proteases are involved in numerous physiological and pathological processes. Here, Sorimachi and colleagues provide an overview of the calpain superfamily and calpain . “Calf Book” is a web based application along with a mobile app to help livestock producers manage their cow/calf data. “Calf Book” allows you to track calving data, calf weaning and yearling performance and generate reports by Sire or entire calf crop.   Calpain Methods and Protocols by John S. Elce, Febru , Humana Press edition, Hardcover in English - 1 editionPages: Alan Wells, Anna Huttenlocher, in Handbook of Cell Signaling, Calpain in Muscular Dystrophy. Calpain 3 is the skeletal muscle–specific calpain isoform. Defects in the human calpain 3 gene are responsible for a form of muscular dystrophy, limb girdle muscular dystrophy type 2A [56].A calpain 3–deficient mouse model also shows a progressive muscular dystrophy with perturbations in.